English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/11724
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Fluorescent Phenylpolyene Analogues of the Ether Phospholipid Edelfosine for the Selective Labeling of Cancer Cells

AuthorsQuesada, Ernesto ; Delgado, Javier; Gajate, Consuelo; Mollinedo, Faustino ; Acuña, A. Ulises ; Amat-Guerri, Francisco
Issue Date21-Sep-2004
PublisherAmerican Chemical Society
CitationJournal of medicinal chemistry 47 (22) : 5333-5335 (2004)
AbstractEdelfosine (ET-18-OCH3), a synthetic antitumor ether lipid, is taken up by malignant but not by normal cells, triggering apoptosis in a large variety of human tumor cells. The synthesis of the first fluorescent edelfosine analogue (6), with apoptotic activity comparable to that of the parent drug, is described. Fluorescence microscopy experiments show that 6 selectively labels human cancer cells, accumulating into specific domains of the plasma membrane.
Publisher version (URL)http://dx.doi.org/10.1021/jm049808a
URIhttp://hdl.handle.net/10261/11724
DOI10.1021/jm049808a
ISSN0022-2623
Appears in Collections:(IBMCC) Artículos
(IQOG) Artículos
(IQFR) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.