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Title: | Fluorescent Phenylpolyene Analogues of the Ether Phospholipid Edelfosine for the Selective Labeling of Cancer Cells |
Authors: | Quesada, Ernesto ![]() ![]() ![]() |
Issue Date: | 21-Sep-2004 |
Publisher: | American Chemical Society |
Citation: | Journal of medicinal chemistry 47 (22) : 5333-5335 (2004) |
Abstract: | Edelfosine (ET-18-OCH3), a synthetic antitumor ether lipid, is taken up by malignant but not by normal cells, triggering apoptosis in a large variety of human tumor cells. The synthesis of the first fluorescent edelfosine analogue (6), with apoptotic activity comparable to that of the parent drug, is described. Fluorescence microscopy experiments show that 6 selectively labels human cancer cells, accumulating into specific domains of the plasma membrane. |
Publisher version (URL): | http://dx.doi.org/10.1021/jm049808a |
URI: | http://hdl.handle.net/10261/11724 |
DOI: | 10.1021/jm049808a |
ISSN: | 0022-2623 |
Appears in Collections: | (IBMCC) Artículos (IQOG) Artículos (IQFR) Artículos |
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