Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/116859
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Ubiquitination of apoptotic cells in the developing cerebellum of the rat following ionizing radiation or methylazoxymethanol injection |
Autor: | Ferrer, Isidro; Pozas, Esther CSIC; Planas, Anna M. CSIC ORCID | Palabras clave: | Ubiquitin Methylazoxymethanol Ionizing radiations Developing nervous system Apoptosis |
Fecha de publicación: | 1997 | Editor: | Springer Nature | Citación: | Acta Neuropathologica 93(4): 402-407 (1997) | Resumen: | Previous studies have shown ubiquitin mRNA induction and protein expression associated with regressive phenomena in some cases of developmentally programmed cell death and experimentally induced apoptosis. Ubiquitin immunoreactivity was examined in the developing cerebellum of the rat following ionizing radiation or methylazoxymethanol (MAM) injection. In irradiated rats, apoptotic cells in the external granule cell layer appeared at 3 h, peaked at 6 h, and decreased thereafter to reach nearly normal values at 48 h. In MAM-treated rats, apoptotic cells in the external granule cell layer were seen at 24 h, peaked at 48 h, and decreased at 72 h. Strong ubiquitin expression was observed in about 15% of apoptotic cells at later stages of apoptosis in both experimental models of induced cell death. In irradiated rats, strong ubiquitin immunoreactivity in apoptotic cells and cellular debris was observed 12 h after irradiation, peaking at 24 h, and decreasing at 48 h. In MAM-treated rats, strong ubiquitin immunoreactivity was found in apoptotic cells and cellular debris at 48 h and decreased at 72 h. Results suggest that activation of the ubiquitin pathway is not a signal that triggers apoptosis but rather a final step in the apoptotic process. | Versión del editor: | http://dx.doi.org/10.1007/s004010050631 | URI: | http://hdl.handle.net/10261/116859 | DOI: | 10.1007/s004010050631 | Identificadores: | doi: 10.1007/s004010050631 issn: 0001-6322 |
Aparece en las colecciones: | (IIBB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
10
checked on 20-abr-2024
WEB OF SCIENCETM
Citations
10
checked on 18-feb-2024
Page view(s)
233
checked on 23-abr-2024
Download(s)
97
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.