Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/116713
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests |
Autor: | López-Gil, Xavier CSIC ORCID; Amat-Roldan, Ivan; Tudela, Raúl; Castañé, Anna CSIC ORCID; Prats-Galino, Alberto; Planas, Anna M. CSIC ORCID; Farr, Tracy D.; Soria, Guadalupe CSIC ORCID | Palabras clave: | DWI DTI Connectomics executive function vascular cognitive impairment Animal models in-vivo MRI hypertension |
Fecha de publicación: | 23-jul-2014 | Editor: | Frontiers Media | Citación: | Frontiers in Aging Neuroscience 6: article 167, 1-13 (2014) | Resumen: | The identification of biomarkers of vascular cognitive impairment is urgent for its early diagnosis. The aim of this study was to detect and monitor changes in brain structure and connectivity, and to correlate them with the decline in executive function. We examined the feasibility of early diagnostic magnetic resonance imaging to predict cognitive impairment before onset in an animal model of chronic hypertension: Spontaneously Hypertensive Rats. Cognitive performance was tested in an operant conditioning paradigm that evaluated learning, memory and behavioral flexibility skills. Behavioral tests were coupled with longitudinal diffusion weighted imaging acquired with 126 diffusion gradient directions and 0.3 mm3 isometric resolution at 10, 14, 18, 22, 26 and 40 weeks after birth. Diffusion weighted imaging was analyzed in 2 different ways, by regional characterization of diffusion tensor imaging indices, and by assessing changes in structural brain network organization based on Q-Ball tractography. Already at the first evaluated times, diffusion tensor imaging scalar maps revealed significant differences in many regions, suggesting loss of integrity in white and grey matter of spontaneously hypertensive rats when compared to normotensive control rats. In addition, graph theory analysis of the structural brain network demonstrated a significant decrease of hierarchical modularity, global and local efficacy, with predictive value as shown by regional 3-fold cross validation study. Moreover, these decreases were significantly correlated with the behavioral performance deficits observed at subsequent time points, suggesting that the diffusion weighted imaging and connectivity studies can unravel neuroimaging alterations even overt signs of cognitive impairment become apparent. | Versión del editor: | http://dx.doi.org/10.3389/fnagi.2014.00167 | URI: | http://hdl.handle.net/10261/116713 | DOI: | 10.3389/fnagi.2014.00167 | Identificadores: | doi: 10.3389/fnagi.2014.00167 issn: 1663-4365 |
Aparece en las colecciones: | (IIBB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Lopez-Gil-fnagi-06-00167.pdf | 3,52 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
16
checked on 07-feb-2024
SCOPUSTM
Citations
21
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
22
checked on 23-feb-2024
Page view(s)
313
checked on 19-abr-2024
Download(s)
280
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.