Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/116234COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Título: | The APC/C activator FZR1 is essential for meiotic prophase I in mice |
Autor: | Holt, Janet E.; García-Higuera, Irene CSIC ORCID; Moreno, Sergio CSIC ORCID; Rodríguez, Rubén CSIC ORCID | Fecha de publicación: | 2014 | Editor: | Company of Biologists | Citación: | Development 141(6): 1354-1365 (2014) | Resumen: | Fizzy-related 1 (FZR1) is an activator of the Anaphase promoting complex/cyclosome (APC/C) and an important regulator of the mitotic cell division cycle. Using a germ-cell-specific conditional knockout model we examined its role in entry into meiosis and early meiotic events in both sexes. Loss of APC/CFZR1 activity in the male germline led to both a mitotic and a meiotic testicular defect resulting in infertility due to the absence of mature spermatozoa. Spermatogonia in the prepubertal testes of such mice had abnormal proliferation and delayed entry into meiosis. Although early recombination events were initiated, male germ cells failed to progress beyond zygotene and underwent apoptosis. Loss of APC/CFZR1 activity was associated with raised cyclin B1 levels, suggesting that CDK1 may trigger apoptosis. By contrast, female FZR1Δ mice were subfertile, with premature onset of ovarian failure by 5 months of age. Germ cell loss occurred embryonically in the ovary, around the time of the zygotenepachytene transition, similar to that observed in males. In addition, the transition of primordial follicles into the growing follicle pool in the neonatal ovary was abnormal, such that the primordial follicles were prematurely depleted. We conclude that APC/CFZR1 is an essential regulator of spermatogonial proliferation and early meiotic prophase I in both male and female germ cells and is therefore important in establishing the reproductive health of adult male and female mammals. © 2014. Published by The Company of Biologists Ltd. | Descripción: | et al. | URI: | http://hdl.handle.net/10261/116234 | DOI: | 10.1242/dev.104828 | Identificadores: | issn: 0950-1991 e-issn: 1477-9129 |
| Aparece en las colecciones: | (IBFG) Artículos (IBMCC) Artículos |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| accesoRestringido.pdf | 15,38 kB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
22
checked on 14-mar-2024
WEB OF SCIENCETM
Citations
22
checked on 24-feb-2024
Page view(s)
329
checked on 18-abr-2024
Download(s)
132
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.