English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/116205
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Título

F-BAR domain protein Rga7 collaborates with Cdc15 and Imp2 to ensure proper cytokinesis in fission yeast

AutorMartín-García, Rebeca ; Coll, Pedro M.; Pérez, Pilar
Fecha de publicación2014
EditorCompany of Biologists
CitaciónJournal of Cell Science 127: 4146- 4158 (2014)
ResumenF-BAR domain proteins act as linkers between the cell cortex and cytoskeleton and are involved in membrane binding and bending. Rga7 is one of the seven F-BAR proteins present in fission yeast. In addition to the F-BAR domain at the N-terminal region, Rga7 possesses a Rho-GAP domain at its C-terminus. We show here that Rga7 is necessary to prevent contracting ring fragmentation and incorrect septum synthesis. Accordingly, cultures of cells lacking Rga7 contain a higher percentage of dividing cells and more frequent asymmetric or aberrant septa, which ultimately may cause cell death. Rga7 F-BAR domain is necessary for the protein localization to the division site and to the cell tips and also for the Rga7 roles in cytokinesis. In contrast, Rga7 GAP catalytic activity seems to be dispensable. Moreover, we demonstrate that Rga7 cooperates with the two F-BAR proteins Cdc15 and Imp2 to ensure proper cytokinesis. We have also detected association of Rga7 with Imp2, and its binding partners Fic1 and Pxl1. Altogether, our findings suggest that Rga7 forms part of a protein complex that coordinates late stages of cytokinesis
Versión del editorhttp://dx.doi.org/10.1242/jcs.146233
URIhttp://hdl.handle.net/10261/116205
DOI10.1242/jcs.146233
Identificadoresdoi: 10.1242/jcs.146233
issn: 0021-9533
e-issn: 1477-9137
Aparece en las colecciones: (IBFG) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
F-BAR domain.pdf3,26 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.