English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/116159
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Bacterial toxin-antitoxin systems targeting translation

AuthorsDíaz-Orejas, Ramón ; Diago-Navarro, Elizabeth ; Hernández-Arriaga, A.M. ; López-Villarejo, Juan ; Lemonnier, Marc ; Moreno-Córdoba, Inmaculada; Nieto, Concha ; Espinosa, Manuel
KeywordsToxin-antitoxin systems
Plasmid maintenance
Cell growth regulation
Toxin RNases
Protein synthesis inhibition
Issue Date17-May-2010
CitationJ Appl Biomed 8:179–188, 2010
AbstractToxin-antitoxin systems (TAS) emerged more than 25 years ago and have since developed as an important field in molecular microbiology. TAS are autoregulated operons coding a stable toxin and an unstable antitoxin found in the plasmids and chromosomes of Bacteria and Archaea. The conditional activation of their toxins interferes with cell growth/viability and, depending on the context, can influence plasmid maintenance,stress management, bacterial persistence, cell differentiation and, it is likely also bacterial virulence. This review summarizes recent results on the parD system of plasmid R1 and on the chromosomal relBE systems found in Escherichia coli and in Streptococcus pneumoniae with a focus on the RNase activity of their toxins,their regulation and their biomedical applications and implications.
Description10 p.-2 fig.
Publisher version (URL)http://dx.doi.org/ 10.2478/v10136-009-0021-9
Appears in Collections:(CIB) Artículos
Files in This Item:
File Description SizeFormat 
J.Appl. Biomed._R. díaz-Orejas_2010.pdf142,02 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.