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http://hdl.handle.net/10261/115041
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dc.contributor.author | Sala-Vila, Aleix | - |
dc.contributor.author | Romero-Mamani, Edwin Saúl | - |
dc.contributor.author | Gilabert, Rosa | - |
dc.contributor.author | Núñez, Isabel | - |
dc.contributor.author | Torre, Rafael de la | - |
dc.contributor.author | Corella, Dolores | - |
dc.contributor.author | Ruiz-Gutiérrez, Valentina | - |
dc.contributor.author | López-Sabater, Carmen | - |
dc.contributor.author | Pintó, Xavier | - |
dc.contributor.author | Rekondo, Javier | - |
dc.contributor.author | Martínez-González, Miguel Ángel | - |
dc.contributor.author | Estruch, Ramón | - |
dc.contributor.author | Ros, Emilio | - |
dc.date.accessioned | 2015-05-12T11:22:49Z | - |
dc.date.available | 2015-05-12T11:22:49Z | - |
dc.date.issued | 2014 | - |
dc.identifier | doi: 10.1161/ATVBAHA.113.302327 | - |
dc.identifier | issn: 1079-5642 | - |
dc.identifier.citation | Arteriosclerosis, Thrombosis, and Vascular Biology 34: 439- 445 (2014) | - |
dc.identifier.uri | http://hdl.handle.net/10261/115041 | - |
dc.description.abstract | OBJECTIVE - : The Prevención con Dieta Mediterránea (PREDIMED) trial showed that a Mediterranean diet (MedDiet) supplemented with either extra virgin olive oil or 30 g/d of mixed nuts reduced incident cardiovascular events compared with a control (low fat) diet. The mechanisms of cardiovascular protection afforded by MedDiets remain to be uncovered. We assessed the effect of both supplemented MedDiets on internal carotid intima-media thickness (ICA-IMT) and plaque height, the ultrasound features that best predict future cardiovascular events, in subjects at high cardiovascular risk. APPROACH AND RESULTS - : In a PREDIMED subcohort (n=175), plaque height and carotid IMT of 3 prespecified segments (ICA, bifurcation, and common) were sonographically assessed at baseline and after intervention for a mean of 2.4 years. We evaluated 164 subjects with complete data. In a multivariate model, mean ICA-IMT progressed in the control diet group (mean [95% confidence interval], 0.052 mm [-0.014 to 0.118 mm]), whereas it regressed in the MedDiet+nuts group (-0.084 mm [-0.158 to -0.010 mm]; P=0.024 versus control). Similar results were observed for maximum ICA-IMT (control, 0.188 mm [0.077 to 0.299 mm]; MedDiet+nuts, -0.030 mm [-0.153 to 0.093 mm]; P=0.034) and maximum plaque height (control, 0.106 mm [0.001 to 0.210 mm]; MedDiet+nuts, -0.091 mm [-0.206 to 0.023 mm]; P=0.047). There were no changes in ICA-IMT or plaque after the MedDiet+extra virgin olive oil. CONCLUSIONS - : Compared with a control diet, consumption of a MedDiet supplemented with nuts is associated with delayed progression of ICA-IMT and plaque. The results contribute mechanistic evidence for the reduction of cardiovascular events observed in the PREDIMED trial. © 2013 American Heart Association, Inc. | - |
dc.description.sponsorship | This work was supported in part by ISCIII (Spanish Ministry of Economy) through grants RTIC G03/140, RTIC RD 06/0045, Centro Nacional de Investigaciones Cardiovasculares CNIC 06/2007, ISCIII FIS PS09/01292, and the Spanish Ministry of Science and Innovation (MICINN): AGL2010-22319-C03-02 and AGL2009-13906-C02-02. A. Sala-Vila was supported by postdoctoral contract FIS CD07/0083. CIBERobn is an initiative of ISCIII, Spain. | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.rights | closedAccess | - |
dc.subject | Nuts | - |
dc.subject | Olive oil | - |
dc.subject | Diet, Mediterranean | - |
dc.subject | Carotid stenosis | - |
dc.subject | Carotid intima-media thickness | - |
dc.title | Changes in ultrasound-assessed carotid intima-media thickness and plaque with a mediterranean diet: A substudy of the PREDIMED trial | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1161/ATVBAHA.113.302327 | - |
dc.date.updated | 2015-05-12T11:22:49Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
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