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The bivalent ligand approach as a tool for improving the in vitro anti-alzheimer multitarget profile of dimebon

AuthorsRosini, M.; Simoni, E.; Bartolini, Manuela; Soriano, Elena ; Marco-Contelles, José ; Andrisano, V.; Monti, B.; Windisch, M.; Hutter-Paier, B.; McClymont, D. W.; Mellor, I. R.; Bolognesi, Maria Laura
KeywordsAlzheimer’s disease
Amyloid aggregation
Dual binding inhibitors
NMDA receptors
Issue Date2013
CitationChemMedChem 8: 1276-1281 (2013)
AbstractInspired by the concept of bivalent ligands, we prepared a small set of analogues of the drug candidate dimebon. They were shown to inhibit AChE, Aβ42 aggregation, and NMDA receptor activation to a greater extent than dimebon. Some of these compounds also enhanced the survival of chicken neurons under apoptosis-inducing conditions.
Identifiersdoi: 10.1002/cmdc.201300263
issn: 1860-7187
e-issn: 1860-7179
Appears in Collections:(IQOG) Artículos
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