Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/114413
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Romero Jódar, Alejandro | - |
dc.contributor.author | Forn-Cuní, Gabriel | - |
dc.contributor.author | Moreira, Rebeca | - |
dc.contributor.author | Milan, Massimo | - |
dc.contributor.author | Bargelloni, Luca | - |
dc.contributor.author | Figueras Huerta, Antonio | - |
dc.contributor.author | Novoa, Beatriz | - |
dc.date.accessioned | 2015-04-29T08:10:16Z | - |
dc.date.available | 2015-04-29T08:10:16Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Fish and Shellfish Immunology 43(1): 275-286 (2014) | es_ES |
dc.identifier.issn | 050-4648 | - |
dc.identifier.uri | http://hdl.handle.net/10261/114413 | - |
dc.description | 12 páginas, 7 figuras, 3 tablas, 1 apéndice | es_ES |
dc.description.abstract | Parasites of the genus Perkinsus cause high mortality and economic losses in bivalves commonly produced in global aquaculture. Although the immune responses of oysters and clams naturally infected with Perkinsus marinus or Perkinsus olseni have been extensively studied, there is not much information on host response at the early stages of infection. In this study, we analysed how P. olseni influences the gene expression profiles of haemocytes from the Manila clam (Venerupis philippinarum) using temporal experimental infections and an immune-enriched microarray. We identified an early phase of infection that was characterised by no mortality and by the increased expression of genes associated with pathogen recognition, production of nitrogen radicals and antimicrobial activity. Cellular processes such as inhibition of serine proteases and proliferation were also involved in this early response. This phase was followed by an intermediate stage, when the pathogen was most likely multiplying and infecting new areas of the body, and animals began to die. In this stage, many genes related to cell movement were over-expressed. Thirty days after infection metabolic pathway genes were the most affected. Apoptosis appears to be important during pathogenesis. Our results provide novel observations of the broader innate immune response triggered by P. olseni at different infection stages | es_ES |
dc.description.sponsorship | This work was partially funded by the EU Project REPROSEED (245119) and European structural funds (FEDER)/Ministerio de Ciencia e Innovación (CSIC08-1E-102). RM thanks the Spanish MICINN for an FPI Spanish research grant (BES-2009-029765). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Venerupis philippinarum | es_ES |
dc.subject | Perkinsus | es_ES |
dc.subject | Oligo-microarray | es_ES |
dc.subject | Immune response | es_ES |
dc.subject | Apoptosis | es_ES |
dc.title | An immune-enriched oligo-microarray analysis of gene expression in Manila clam (Venerupis philippinarum) haemocytes after a Perkinsus olseni challenge | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.fsi.2014.12.029 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.fsi.2014.12.029 | es_ES |
dc.identifier.e-issn | 1095-9947 | - |
dc.relation.csic | Sí | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (IIM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Immune-enriched_oligo-microarray analysis.pdf | 625,35 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
22
checked on 21-abr-2024
WEB OF SCIENCETM
Citations
21
checked on 29-feb-2024
Page view(s)
400
checked on 24-abr-2024
Download(s)
529
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.