Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/114082
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Nonimmune cells contribute to crosstalk between immune cells and inflammatory mediators in the innate response to Trypanosoma cruzi infection |
Autor: | Aoki, Maria Pilar; Carrera-Silva, Eugenio Antonio; Cuervo, Henar CSIC ORCID; Fresno, Manuel CSIC ORCID ; Gironès, Núria CSIC ORCID; Gea, Susana | Palabras clave: | Trypanosoma cruzi Chagas disease Myocarditis Immune cells |
Fecha de publicación: | 2012 | Editor: | Hindawi Publishing Corporation | Citación: | Journal of Parasitology Research 2012, Art ID 737324 (2012) | Resumen: | Chagas myocarditis, which is caused by infection with the intracellular parasite Trypanosoma cruzi, remains the major infectious heart disease worldwide. Innate recognition through toll-like receptors (TLRs) on immune cells has not only been revealed to be critical for defense against T. cruzi but has also been involved in triggering the pathology. Subsequent studies revealed that this parasite activates nucleotide-binding oligomerization domain- (NOD-)like receptors and several particular transcription factors in TLR-independent manner. In addition to professional immune cells, T. cruzi infects and resides in different parenchyma cells. The innate receptors in nonimmune target tissues could also have an impact on host response. Thus, the outcome of the myocarditis or the inflamed liver relies on an intricate network of inflammatory mediators and signals given by immune and nonimmune cells. In this paper, we discuss the evidence of innate immunity to the parasite developed by the host, with emphasis on the crosstalk between immune and nonimmune cell responses | URI: | http://hdl.handle.net/10261/114082 | DOI: | 10.1155/2012/737324 | Identificadores: | doi: 10.1155/2012/737324 issn: 2090-0023 |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Manuel_Fresno_Nonimmune_Cells.pdf | 1,23 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
12
checked on 27-mar-2024
SCOPUSTM
Citations
15
checked on 28-mar-2024
Page view(s)
255
checked on 29-mar-2024
Download(s)
139
checked on 29-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.