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Título

Nonimmune cells contribute to crosstalk between immune cells and inflammatory mediators in the innate response to Trypanosoma cruzi infection

AutorAoki, Maria Pilar; Carrera-Silva, Eugenio Antonio; Cuervo, Henar CSIC ORCID; Fresno, Manuel CSIC ORCID ; Gironès, Núria CSIC ORCID; Gea, Susana
Palabras claveTrypanosoma cruzi
Chagas disease
Myocarditis
Immune cells
Fecha de publicación2012
EditorHindawi Publishing Corporation
CitaciónJournal of Parasitology Research 2012, Art ID 737324 (2012)
ResumenChagas myocarditis, which is caused by infection with the intracellular parasite Trypanosoma cruzi, remains the major infectious heart disease worldwide. Innate recognition through toll-like receptors (TLRs) on immune cells has not only been revealed to be critical for defense against T. cruzi but has also been involved in triggering the pathology. Subsequent studies revealed that this parasite activates nucleotide-binding oligomerization domain- (NOD-)like receptors and several particular transcription factors in TLR-independent manner. In addition to professional immune cells, T. cruzi infects and resides in different parenchyma cells. The innate receptors in nonimmune target tissues could also have an impact on host response. Thus, the outcome of the myocarditis or the inflamed liver relies on an intricate network of inflammatory mediators and signals given by immune and nonimmune cells. In this paper, we discuss the evidence of innate immunity to the parasite developed by the host, with emphasis on the crosstalk between immune and nonimmune cell responses
URIhttp://hdl.handle.net/10261/114082
DOI10.1155/2012/737324
Identificadoresdoi: 10.1155/2012/737324
issn: 2090-0023
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