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Steroids synthesis and growth control

AuthorsBarrio, Rosa; Talamillo, Ana; Herboso, Leire; Pérez, Coralia; Martín Casacuberta, David A. ; Sutherland, James D.
Issue DateOct-2013
Citation23rd European Drosophila Research Congress (2013)
AbstractThe steroid hormone ecdysone is produced in the prothoracic gland (PG) of insects. There, cholesterol intake is needed as source for ecdysone synthesis. We have demonstrated that the small ubiquitin-related modifier SUMO is necessary for lipid uptake in the PG. SUMO is required for the expression of Ftz-f1, an orphan nuclear receptor, which is in turn necessary for the expression of some members of the Scavenger Receptor Class B type I (SR-BI) family. These receptors belong to the mammalian CD36 family, which participates in the selective uptake of High Density Lipoprotein cholesteryl ester and in the formation of microvillar channels in the mammalian adrenal gland. Our results show that the SR-BI Snmp1 is involved in the cholesterol uptake mediated by SUMO and Ftz-f1. Snmp1 overexpression is able to rescue the lipid capture in PGs silenced for SUMO or Ftzf1. Furthermore, the requirement of SUMO/Ftz-f1/SR-BIs for lipid capture is conserved in other tissues. The ecdysone produced in the PG has non-autonomous consequences on the growth of other larval tissues, such as the imaginal discs. Without ecdysone, imaginal discs do not reach the proper size due to a reduction in cell proliferation and cell size. These parameters are recovered when the hormone is exogenously administrated. We are investigating the factors implicated in cell growth triggered by ecdysone.
DescriptionPóster presentado en el 23rd European Drosophila Research Congress, celebrado en Barcelona del 16 al 19 de octubre de 2013.
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