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dc.contributor.authorJiménez-Girón, Ana-
dc.contributor.authorIbáñez, Clara-
dc.contributor.authorCifuentes, Alejandro-
dc.contributor.authorSimó, Carolina-
dc.contributor.authorMuñoz-González, Irene-
dc.contributor.authorMartín-Álvarez, Pedro J.-
dc.contributor.authorBartolomé, Begoña-
dc.contributor.authorMoreno-Arribas, M. Victoria-
dc.date.accessioned2015-04-16T08:07:47Z-
dc.date.available2015-04-16T08:07:47Z-
dc.date.issued2015-
dc.identifierdoi: 10.1021/pr500960g-
dc.identifierissn: 1535-3893-
dc.identifiere-issn: 1535-3907-
dc.identifier.citationJournal of Proteome Research 14(2): 897-905 (2015)-
dc.identifier.urihttp://hdl.handle.net/10261/113735-
dc.description.abstractFaecal metabolome contains information on the metabolites found in the intestine, from which knowledge about the metabolic function of the gut microbiota can be obtained. Changes in the metabolomic profile of faeces reflect, among others, changes in the composition and activity of the intestinal microorganisms. In an effort to improve our understanding of the biological effects that phenolic compounds (including red wine polyphenols) exert at the gut level, in this foodomic study we have undertaken a metabolome characterization of human faeces after moderate consumption of red wine by healthy subjects for 4 weeks. Namely, a nontargeted metabolomic approach based on the use of UHPLC-TOF MS was developed to achieve the maximum metabolite information on 82 human faecal samples. After data processing and statistical analysis, 37 metabolites were related to wine intake, from which 20 could be tentatively or completely identified, including the following: (A) wine compounds, (B) microbial-derived metabolites of wine polyphenols, and (C) endogenous metabolites and/or others derived from other nutrient pathways. After wine consumption, faecal metabolome was fortified in flavan-3-ols metabolites. Also, of relevance was the down regulation of xanthine and bilirubin-derived metabolites such as urobilinogen and stercobilin after moderate wine consumption. As far as we know, this is the first study of the faecal metabolome after wine intake.-
dc.description.sponsorshipThis work has been developed in the Metabolomics Platform at CIAL, and it has been funded by the Spanish Ministry of Economy and Competitiveness (Project AGL2012-40172-C02-01). A.J.-G. and I.M.-G. thank the European Social Fund and JAE-DOC program (CSIC) and the FPI (MINECO) program, respectively.-
dc.publisherAmerican Chemical Society-
dc.rightsclosedAccess-
dc.subjectLC-TOF MS-
dc.subjectMetabolomics-
dc.subjectWine polyphenols-
dc.subjectFaecal metabolome-
dc.titleFaecal metabolomic fingerprint after moderate consumption of red wine by healthy subjects-
dc.typeartículo-
dc.identifier.doi10.1021/pr500960g-
dc.date.updated2015-04-16T08:07:47Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderEuropean Commission-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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