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Título: | Structural differences of prebiotic oligosaccharides influence their capability to enhance iron absorption in deficient rats |
Autor: | Laparra, José Moisés CSIC ORCID; Díez-Municio, M. CSIC ORCID; Herrero, Miguel CSIC ORCID CVN ; Herrero, Miguel CSIC ORCID CVN ; Moreno, F. Javier CSIC ORCID | Fecha de publicación: | 2014 | Editor: | Royal Society of Chemistry (UK) | Citación: | Food and Function 5(10): 2430-2437 (2014) | Resumen: | This study evaluates the influence of novel galacto-oligosaccharides derived from lactulose (GOS-Lu), kojibiose or 4′-galactosyl-kojibiose in hematological parameters of Fe homeostasis using Fe-deficient animals. Liver TfR-2, IL-6, NFκB and PPAR-γ expression (mRNA) were also determined by RT-qPCR analyses, and active hepcidin peptide production and short chain fatty acids by LC coupled to MS/MS or UV detection. Feeding animals with GOS-Lu or kojibiose together with FeCl3 increased hemoglobin (Hb) production (by 17%) and mean Hb concentration into erythrocytes relative to animals administered with FeCl3 alone (14.1% and 19.7%, respectively). Animals administered with prebiotics showed decreased plasmatic hepcidin levels, contributing to a higher intestinal absorption of the micronutrient. These data indicate that concurrent administration of these potentially prebiotic oligosaccharides together with a supplement of Fe ameliorates inflammation-mediated perturbations in the liver, according to the particular structure of the prebiotic compound, and result an attractive strategy to improve Fe absorption. | Versión del editor: | http://dx.doi.org/10.1039/c4fo00504j | URI: | http://hdl.handle.net/10261/113646 | DOI: | 10.1039/c4fo00504j | ISSN: | 2042-6496 | E-ISSN: | 2042-650X |
Aparece en las colecciones: | (CIAL) Artículos |
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