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Computational studies on biphenyl derivatives. Analysis of the conformational mobility, molecular electrostatic potential, and dipole moment of chlorinated biphenyl: searching for the rationalization of the selective toxicity of polychlorinated biphenyls (PCBs)

AuthorsChana López, Antonio ; Concejero, Miguel A. ; Frutos, Mercedes de ; González, María J.; Herradón García, Bernardo
Issue Date16-Dec-2002
PublisherAmerican Chemical Society
CitationChemical Research in Toxicology 15(12): 1514-1526 (2002)
AbstractWith the objective to understand how the pattern and degree of chlorination influence on the properties of the title molecules, a computational study on biphenyl and all the chlorinated biphenyls (from 1 to 10 chlorine atoms, 209 congeners) has been undertaken. The study includes conformational searches (and further refinement by molecular dynamics simulations) and the ab initio calculation of the molecular electrostatic potential (MEP) and the dipole moments for all the congeners. The most significant property is the MEP, finding a good correlation between the MEPs and the substitution pattern on chlorinated biphenyls. The most toxic congeners possess highly positive values of electrostatic potential on the aromatic rings and highly negative values of electrostatic potential on the chlorine atoms. Additionally, we have found that the toxic congeners possess conformations with low dipole moments, a fact that may be linked to the ready accumulation on the adipose tissue. The results on the geometry and electrostatic properties of chlorinated biphenyls can be useful to rationalize their selective toxicities.
Description13 pages, 8 figures.-- PMID: 12482233 [PubMed].-- Taken in part from the projected Ph. D. thesis of A.C.
Supporting information available: The molecular surface electrostatic potentials and the dipole moments of biphenyl and the 209 chlorinated congeners and the coordinates and the energies of the 209 PCBs resulting from the ab initio calculations. Available at: http://pubs.acs.org/doi/suppl/10.1021/tx025596d
Publisher version (URL)http://dx.doi.org/10.1021/tx025596d
Appears in Collections:(IQOG) Artículos
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