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GTL1 keeps cell growth and nuclear ploidy under control

AuthorsCaro, Elena ; Desvoyes, Bénédicte ; Gutiérrez Armenta, Crisanto
Issue Date2012
PublisherNature Publishing Group
CitationEMBO Journal 31: 4483- 4485 (2012)
AbstractThe endoreplication programme consists of multiple rounds of full genome replication in the absence of any intervening mitosis. This leads to an increase in nuclear ploidy that has been linked to the initiation of cell differentiation and growth. Recent work (Breuer et al, 2012) has identified the GTL1 transcription factor as a master regulator of cell growth through two different mechanisms: one, endoreplication dependent where GTL1 acts as a repressor of the anaphase-promoting complex (APC), and another as a regulator of endoreplication-independent cell growth. © 2012 European Molecular Biology Organization.
Identifiersdoi: 10.1038/emboj.2012.311
issn: 0261-4189
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