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Novel tacrine-grafted ugi adducts as multipotent anti-alzheimer drugs: A synthetic renewal in tacrine-ferulic acid hybrids

AuthorsBenchekroun, M.; Bartolini, Manuela; Egea, Javier; Romero, A. ; Soriano, Elena ; Pudlo, M.; Luzet, Vincenza; Andrisano, V.; Jimeno, M. Luisa ; López, M. G.; Wehle, S.; Gharbi, T.; Refouvelet, B.; Andrés, L. de; Herrera-Arozamena, Clara; Monti, B.; Bolognesi, Maria Laura; Rodríguez-Franco, María Isabel ; Decker, M.; Marco-Contelles, José ; Ismaili, L.
multicomponent reactions
Alzheimer’s disease
Issue Date2015
CitationChemMedChem 10: 523-539 (2015)
AbstractHerein we describe the design, multicomponent synthesis, and biological, molecular modeling and ADMET studies, as well as in vitro PAMPA-blood-brain barrier (BBB) analysis of new tacrine-ferulic acid hybrids (TFAHs). We identified (E)-3-(hydroxy-3-methoxyphenyl)-N-{8[(7-methoxy-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl}-N-[2-(naphthalen-2-ylamino)2-oxoethyl]acrylamide (TFAH 10n) as a particularly interesting multipotent compound that shows moderate and completely selective inhibition of human butyrylcholinesterase (IC50 = 68.2 nm ), strong antioxidant activity (4.29 equiv trolox in an oxygen radical absorbance capacity (ORAC) assay), and good β-amyloid (Aβ) anti-aggregation properties (65.6% at 1:1 ratio); moreover, it is able to permeate central nervous system (CNS) tissues, as determined by PAMPA-BBB assay. Notably, even when tested at very high concentrations, TFAH 10n easily surpasses the other TFAHs in hepatotoxicity profiling (59.4% cell viability at 1000 μm), affording good neuroprotection against toxic insults such as Aβ1-40, Aβ1-42, H2O2, and oligomycin A/rotenone on SH-SY5Y cells, at 1 μm. The results reported herein support the development of new multipotent TFAH derivatives as potential drugs for the treatment of Alzheimer's disease.
Identifiersdoi: 10.1002/cmdc.201402409
issn: 1860-7187
e-issn: 1860-7187
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