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Título: | Analysing the contribution of nucleic acids to the structure and properties of centric heterochromatin |
Autor: | Cortés, Alfred; Huertas, Dori CSIC; Marsellach, Francesc Xavier CSIC; Ferrer-Miralles, Neus; Ortiz-Lombardía, Miguel CSIC; Fanti, Laura; Pimpinelli, Sergio; Piña, Benjamín CSIC ORCID ; Azorín, Ferran CSIC ORCID | Palabras clave: | DDP1 Scp160p Satellite DNA Multi-KH-domain proteins Dodeca-satellite Vigilins Centromeric heterochromatin DNA structure |
Fecha de publicación: | mar-2003 | Editor: | Kluwer Academic Publishers | Citación: | Genetica 117(2-3): 117-125 (2003) | Resumen: | A class of repetitive DNA sequences frequently found at centromeric regions are R/Y-satellites showing an asymmetric distribution of residues resulting in one strand being rich in purines (R-strand) while the complementary strand is pyrimidine-rich (Y-strand). The dodeca-satellite of Drosophila belongs to this class of centromeric satellites. In vivo, the dodeca-satellite forms altered DNA structures in which the R-strand forms very stable intramolecular fold-backs that are stabilised by the formation of tandem G·A mismatches. A single-stranded nucleic acids binding protein, DDP1, binds the unstructured dodeca-satellite Y-strand with high affinity. In polytene chromosomes, DDP1 associates with the heterochromatic chromocenter and, at the euchromatic chromosome arms, co-localises with HP1. DDP1 is a vigilin. Vigilins are highly conserved multi-KH-domain proteins. Scp160p, the vigilin from S. cerevisiae, is involved in the control of ploidy. DDP1 complements a Δscp160 deletion. | Versión del editor: | http://dx.doi.org/10.1023/A:1022947921402 | URI: | http://hdl.handle.net/10261/112404 | DOI: | 10.1023/A:1022947921402 | Identificadores: | doi: 10.1023/A:1022947921402 issn: 0016-6707 |
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