English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/112296
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


DNA methylation contributes to natural human variation

AuthorsHeyn, Holger; Hernando-Herraez, Irene ; Marqués-Bonet, Tomàs ; Esteller, Manel
Issue Date2013
PublisherCold Spring Harbor Laboratory Press
CitationGenome Research 23: 1363-1372 (2013)
AbstractDNA methylation patterns are important for establishing cell, tissue, and organism phenotypes, but little is known about their contribution to natural human variation. To determine their contribution to variability, we have generated genomescale DNA methylation profiles of three human populations (Caucasian-American, African-American, and Han Chinese-American) and examined the differentially methylated CpG sites. The distinctly methylated genes identified suggest an influence of DNA methylation on phenotype differences, such as susceptibility to certain diseases and pathogens, and response to drugs and environmental agents. DNA methylation differences can be partially traced back to genetic variation, suggesting that differentially methylated CpG sites serve as evolutionarily established mediators between the genetic code and phenotypic variability. Notably, one-third of the DNA methylation differences were not associated with any genetic variation, suggesting that variation in population-specific sites takes place at the genetic and epigenetic levels, highlighting the contribution of epigenetic modification to natural human variation. © 2013, Published by Cold Spring Harbor Laboratory Press.
DescriptionHeyn, Holger el al.-- This article, published in Genome Research, is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported).
Publisher version (URL)http://dx.doi.org/10.1101/gr.154187.112
Identifiersdoi: 10.1101/gr.154187.112
issn: 1088-9051
e-issn: 1549-5469
Appears in Collections:(IBE) Artículos
Files in This Item:
File Description SizeFormat 
DNA_methylation_Heyn.pdf1,39 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.