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Título

Dicer-1 is a key enzyme in the regulation of oogenesis in panoistic ovaries

AutorDonato Tanaca, Erika ; Piulachs, Maria-Dolors
Palabras claveMicroRNA
Cockroach
Drosophila
Juvenile hormone
Blattella germanica
Fecha de publicaciónago-2012
EditorJohn Wiley & Sons
CitaciónBiology of the Cell 104(8): 452-461 (2012)
Resumen[Background information] In insects, the action of microRNAs (miRNAs) on oogenesis has been explored only in dipterans, which possess meroistic ovaries, a highly modified ovarian type. Here we study miRNA function in the most primitive, panoistic type of ovaries using the phylogenetically basal insect Blattella germanica (Dictyoptera, Blattellidae) as model.
[Results] Dicer-1 (Dcr1), a key enzyme in miRNA biogenesis, was depleted using RNAi. Females treated with double-stranded RNA targeting Dicer-1, exhibited deep alterations in oocyte development; among them, the follicular epithelia of the basal oocytes did not develop, thus resulting in sterile females.
[Conclusions] These effects derived from the absence of Dicer-1 suggest that miRNAs are crucial for the regulation of oogenesis in panoistic ovaries, the most primitive insect ovarian type. © 2012 Soçiété Francaise des Microscopies and Société de Biologie Cellulaire de France.
Versión del editorhttp://dx.doi.org/10.1111/boc.201100044
URIhttp://hdl.handle.net/10261/112203
DOI10.1111/boc.201100044
Identificadoresdoi: 10.1111/boc.201100044
issn: 0248-4900
e-issn: 1768-322X
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