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Título: | Upstream deregulation of calcium signaling in Parkinson’s disease |
Autor: | Rivero-Ríos, Pilar; Gómez-Suaga, P.; Fdez, Elena; Hilfiker, Sabine | Palabras clave: | Parkinson’s disease Dopamine Calcium Mitochondria endoplasmic reticulum Lysosomes Golgi |
Fecha de publicación: | 17-jun-2014 | Editor: | Frontiers Media | Citación: | Frontiers in Molecular Neuroscience | Resumen: | Parkinson’s disease (PD) is a major health problem affecting millions of people worldwide. Recent studies provide compelling evidence that altered Ca2+ homeostasis may underlie disease pathomechanism and be an inherent feature of all vulnerable neurons. The downstream effects of altered Ca2+ handling in the distinct subcellular organelles for proper cellular function are beginning to be elucidated. Here, we summarize the evidence that vulnerable neurons may be exposed to homeostatic Ca2+ stress which may determine their selective vulnerability, and suggest how abnormal Ca2+ handling in the distinct intracellular compartments may compromise neuronal health in the context of aging, environmental, and genetic stress. Gaining a better understanding of the varied effects of Ca2+ dyshomeostasis may allow novel combinatorial therapeutic strategies to slow PD progression. | Versión del editor: | http://journal.frontiersin.org/article/10.3389/fnmol.2014.00053/full#h11 | URI: | http://hdl.handle.net/10261/112067 | DOI: | 10.3389/fnmol.2014.00053 | ISSN: | 1662-5099 | E-ISSN: | 1662-5099 |
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