English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/111867
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Chorion formation in panoistic ovaries requires windei and trimethylation of histone 3 lysine 9

AuthorsHerraiz, Alba ; Bellés, Xavier ; Piulachs, Maria-Dolors
Follicular epithelia
Blattella germanica
Issue Date1-Jan-2014
CitationExperimental Cell Research 320(1): 46-53 (2014)
AbstractEpigenetic modifications play key roles in transcriptional regulation. Trimethylation of histone 3 lysine 9 (H3K9me3) is one of the most widely studied histone post-translational modifications, and has been linked to transcriptional repression. In Drosophila melanogaster, Windei is needed for H3K9me3 in female germ line cells. Here, we report the occurrence of a D. melanogaster Windei (Wde) ortholog in the ovary of the hemimetabolous insect Blattella germanica, which we named BgWde. Depletion of BgWde by RNAi reduced H3K9me3 in follicular cells, which triggered changes in transcriptional regulation that led to the prevention of chorion gene expression. In turn, this impaired oviposition (and the formation of the ootheca) and, therefore, prevented reproduction. Windei and H3K9me3 have already been reported in follicular cells of D. melanogaster, but this is the first time that the function of these modifications has been demonstrated in the said cells. This is also the first time that an epigenetic marker is reported as having a key role in choriogenesis. © 2013 Elsevier Inc.
Publisher version (URL)http://dx.doi.org/10.1016/j.yexcr.2013.07.006
Identifiersdoi: 10.1016/j.yexcr.2013.07.006
issn: 0014-4827
Appears in Collections:(IBE) Artículos
Files in This Item:
File Description SizeFormat 
chorion_formation_panoistic_Herraiz.pdf245,07 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.