Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/11183
Título : Spatial Regulation of Cdc42 During Cytokinesis
Autor : Rincón Padilla, Sergio A., Coll, Pedro M., Pérez González, Pilar
Palabras clave : Cdc42
Rho
GTPases
GEF
Cytokinesis
Morphogenesis
Amphiphysin
Fission yeast
Fecha de publicación : 21-May-2007
Editor: Landes Bioscience
Citación : Cell Cycle 6(14): 1687-1691 (2007)
Resumen: Cdc42 GTPase plays a critical role in the establishment of cell polarity in most eukaryotic organisms. Cdc42 active state, as that of other GTPases, depends on the bound nucleotide. The protein with GTP is active, and only in this state can it interact with different target effector proteins. The spatio-temporal control of Cdc42 activity is therefore necessary to generate growth polarity. In fission yeast cells, Cdc42 mainly localizes to the division area, and also to the growing tips and to some internal membranes. While the role of Cdc42 in apical growth is well defined, no role has been described for Cdc42 in the process of cell division. Fission yeast Cdc42 activity is regulated by two specific guanidine nucleotide exchange factors (GEFs), Scd1, and Gef1. We discuss here how Hob3, a BAR domain containing protein similar to human BIN3 and S. cerevisiae Rsv161, may be required to recruit Cdc42 to the cell division site as well as for the activation of this GTPase mediated by Gef1. We also discuss the possible role of Cdc42 in the contraction of the actomyosin ring necessary for cytokinesis.
Descripción : 5 pages, 2 figures.-- PMID: 17637568 [PubMed].-- Printed version published on Jul 15, 2007.
Versión del editor: http://www.landesbioscience.com/journals/cc/article/4481/
URI : http://hdl.handle.net/10261/11183
ISSN: 1538-4101 (Print)
1551-4005 (Online)
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