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dc.contributor.authorGarcía-Junceda, Eduardo-
dc.contributor.authorGarcía-García, Juan Francisco-
dc.contributor.authorBastida, Agatha-
dc.contributor.authorFernández-Mayoralas, Alfonso-
dc.date.accessioned2009-03-03T09:43:32Z-
dc.date.available2009-03-03T09:43:32Z-
dc.date.issued2004-04-15-
dc.identifier.citationBioorg Med Chem. 2004 Apr 15;12(8):1817-34.en_US
dc.identifier.issn0968-0896-
dc.identifier.urihttp://hdl.handle.net/10261/11168-
dc.description.abstractThe growing demand for enantiomerically pure pharmaceuticals has impelled research on enzymes as catalysts for asymmetric synthetic transformations. However, the use of enzymes for this purpose was rather limited until the discovery that enzymes can work in organic solvents. Since the advent of the PCR the number of available enzymes has been growing rapidly and the tailor-made biocatalysts are becoming a reality. Thus, it has been possible the use of enzymes for the synthesis of new innovative medicines such as carbohydrates and their incorporation to modern methods for drug development, such as combinatorial chemistry. Finally, the genomic research is allowing the manipulation of whole genomes opening the door to the combinatorial biosynthesis of compounds. In this review, our intention is to highlight the main landmarks that have led to transfer the chemical efficiency shown by the enzymes in the cell to the synthesis of bioactive molecules in the lab during the last 20 years. In this review, our intention is to highlight the main landmarks of the last 20 years that have led to transfer the chemical efficiency shown by the enzymes in the cell to the synthesis of bioactive molecules in the laboratory.en_US
dc.description.sponsorshipAB was supported by a postdoctoral I3P contract of the European Social Found. This work was supported by the Spanish DGI (Grants BQU2001-1503 and PTR1995-0568-OP).en_US
dc.format.extent731379 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherPergamon Pressen_US
dc.rightsopenAccessen_US
dc.subjectEnzymes in non-aqueous solventsen_US
dc.subjectGlycosyltransferaseen_US
dc.subjectCombinatorial biocatalysisen_US
dc.subjectCombinatorial biosynthesisen_US
dc.subjectEnzymes in polymer-support synthesisen_US
dc.subjectCatalytic antibodiesen_US
dc.titleEnzymes in the Synthesis of Bioactive Compounds: The Prodigious Decadesen_US
dc.typeartículoen_US
dc.identifier.doi10.1016/j.bmc.2004.01.032-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.:10.1016/j.bmc.2004.01.032en_US
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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