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Title

Enzymes in the Synthesis of Bioactive Compounds: The Prodigious Decades

AuthorsGarcía-Junceda, Eduardo ; García-García, Juan Francisco ; Bastida, Agatha; Fernández-Mayoralas, Alfonso
KeywordsEnzymes in non-aqueous solvents
Glycosyltransferase
Combinatorial biocatalysis
Combinatorial biosynthesis:
Enzymes in polymer-support synthesis
Catalytic antibodies:
Issue Date15-Apr-2004
PublisherPergamon Press
CitationBioorg Med Chem. 2004 Apr 15;12(8):1817-34.
AbstractThe growing demand for enantiomerically pure pharmaceuticals has impelled research on enzymes as catalysts for asymmetric synthetic transformations. However, the use of enzymes for this purpose was rather limited until the discovery that enzymes can work in organic solvents. Since the advent of the PCR the number of available enzymes has been growing rapidly and the tailor-made biocatalysts are becoming a reality. Thus, it has been possible the use of enzymes for the synthesis of new innovative medicines such as carbohydrates and their incorporation to modern methods for drug development, such as combinatorial chemistry. Finally, the genomic research is allowing the manipulation of whole genomes opening the door to the combinatorial biosynthesis of compounds. In this review, our intention is to highlight the main landmarks that have led to transfer the chemical efficiency shown by the enzymes in the cell to the synthesis of bioactive molecules in the lab during the last 20 years. In this review, our intention is to highlight the main landmarks of the last 20 years that have led to transfer the chemical efficiency shown by the enzymes in the cell to the synthesis of bioactive molecules in the laboratory.
Publisher version (URL)http://dx.doi.:10.1016/j.bmc.2004.01.032
URIhttp://hdl.handle.net/10261/11168
DOIdoi:10.1016/j.bmc.2004.01.032
ISSN0968-0896
Appears in Collections:(IQOG) Artículos
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