English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/111545
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Campo DC Valor Lengua/Idioma
dc.contributor.authorMelchini, Antonietta-
dc.contributor.authorTraka, Maria-
dc.contributor.authorCatania, Stefania-
dc.contributor.authorMiceli, Natalizia-
dc.contributor.authorTaviano, Maria Fernanda-
dc.contributor.authorMaimone, Patrizia-
dc.contributor.authorFrancisco Candeira, Marta-
dc.contributor.authorMithen, Richard F.-
dc.contributor.authorCosta, Chiara-
dc.identifierdoi: 10.1080/01635581.2013.741747-
dc.identifierissn: 0163-5581-
dc.identifiere-issn: 1532-7914-
dc.identifier.citationNutrition and Cancer 65 (1): 132- 138 (2013)-
dc.description.abstractIt is becoming increasingly clear that many dietary agents, such as isothiocyanates (ITCs) from cruciferous vegetables, can retard or prevent the process of prostate carcinogenesis. Erucin (ER) is a dietary ITC, which has been recently considered a promising cancer chemopreventive phytochemical. The potential protective activity of ER against prostate cancer was investigated using prostate adenocarcinoma cells (PC3), to analyze its effects on pathways involved in cell growth regulation, such as the cyclin-dependent kinase (CDKs) inhibitor p21WAF1/CIP1 (p21), phosphatidylinositol-3 kinase/AKT, and extracellular signal-regulated kinases (ERK)1/2 signaling pathways. We have shown for the first time that ER increases significantly p21 protein expression and ERK1/2 phosphorylation in a dose-dependent manner to inhibit PC3 cell proliferation (P ≤ 0.01). Compared to the structurally related sulforaphane, a well-studied broccoli-derived ITC, ER showed lower potency in inhibiting proliferation of PC3 cells, as well as inmodulating p21 and pERK1/2 protein levels. Neither of the naturally occurring ITCs was able to affect significantly pAKT protein levels in prostate cells at all concentrations tested (0-25 μM). It is clearly important for the translation of laboratory findings to clinical approaches to investigate in animal and cell studies the molecular mechanisms by which ITCs may exert health promoting effects. Copyright © 2013, Taylor & Francis Group, LLC.-
dc.description.sponsorship“Fondazione Prof. Antonio Imbesi” (Messina, Italy)-
dc.publisherLawrence Erlbaum Associates-
dc.titleAntiproliferative activity of the dietary isothiocyanate erucin, a bioactive compound from cruciferous vegetables, on human prostate cancer cells-
dc.description.versionPeer Reviewed-
Aparece en las colecciones: (MBG) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Show simple item record

Artículos relacionados:

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.