Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/111436
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Self-reported sleep duration, white blood cell counts and cytokine profiles in European adolescents: the HELENA study. |
Autor: | Pérez de Heredia, F. CSIC ORCID; Gómez-Martínez, Sonia CSIC ORCID; Díaz-Prieto, Ligia E. CSIC ORCID; Marcos, Ascensión CSIC ORCID | Palabras clave: | Cytokine balance Sleep duration Immune cell profile Inflammation Th1/Th2 Adolescents Gender differences |
Fecha de publicación: | 2014 | Editor: | Elsevier | Citación: | Sleep Medicine 15: 1251- 1258 (2014) | Resumen: | BACKGROUND: Sleep patterns face important changes during adolescence. This can have implications for the immune system, which is regulated by the sleep-wake cycle; however, most studies relating sleep and immune system have been conducted on adults. OBJECTIVE: To study the relationships between sleep duration, immune cell counts, and cytokines in European adolescents participating in the HELENA Cross-Sectional Study. METHODS: Adolescents (12.5-17.5¿years; n¿=¿933; 53.9% girls) were grouped according to self-reported sleep duration into <8, 8-8.9 and ¿9¿h/night. Blood samples were collected in the morning after an overnight fast to analyze counts of white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils, basophils, the lymphocyte subsets CD3(+), CD4(+), CD8(+), CD45RA(+), CD45RO(+), CD3(-)CD16(+)56(+) and CD19(+), and concentrations of cortisol, CRP, IL-1, IL-2, IL-4, IL-5, IL-6, IL-10, TNF-¿ and IFN-¿. Pro-/anti-inflammatory and Th1/Th2 cytokine ratios were calculated. Immune parameters were correlated to sleep duration and compared between the three groups. RESULTS: Sleep duration was negatively associated with cortisol levels and WBC, neutrophil, monocyte, CD4(+) and CD4(+)CD45RO(+) counts; in girls it is also negatively associated with IL-5 and IL-6 levels. The 8-8.9¿h/night group presented the highest IL-4 values and the lowest pro-/anti-inflammatory and Th1/Th2 cytokine ratios. CONCLUSION: A sleep duration of 8-8.9¿h/night was associated with a healthier immune profile in our adolescents. | URI: | http://hdl.handle.net/10261/111436 | DOI: | 10.1016/j.sleep.2014.04.010 | Identificadores: | doi: 10.1016/j.sleep.2014.04.010 issn: 1389-9457 |
Aparece en las colecciones: | (ICTAN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
55
checked on 19-abr-2024
WEB OF SCIENCETM
Citations
51
checked on 25-feb-2024
Page view(s)
309
checked on 24-abr-2024
Download(s)
135
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.