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Título: | A genome-wide survey does not show the genetic distinctiveness of Basques |
Autor: | Laayouni, Hafid CSIC ORCID; Calafell, Francesc CSIC ORCID ; Bertranpetit, Jaume CSIC ORCID | Fecha de publicación: | abr-2010 | Editor: | Springer Nature | Citación: | Human Genetics 127(4): 455-458 (2010) | Resumen: | Basques are a cultural isolate, and, according to mainly allele frequencies of classical polymorphisms, also a genetic isolate. We investigated the differentiation of Spanish Basques from the rest of Iberian populations by means of a dense, genome-wide SNP array. We found that F ST distances between Spanish Basques and other populations were similar to those between pairs of non-Basque populations. The same result is found in a PCA of individuals, showing a general distinction between Iberians and other South Europeans independently of being Basques. Pathogen-mediated natural selection may be responsible for the high differentiation previously reported for Basques at very specific genes such as ABO, RH, and HLA. Thus, Basques cannot be considered a genetic outlier under a general genome scope and interpretations on their origin may have to be revised. © 2010 Springer-Verlag. | Versión del editor: | http://dx.doi.org/10.1007/s00439-010-0798-3 | URI: | http://hdl.handle.net/10261/111349 | DOI: | 10.1007/s00439-010-0798-3 | Identificadores: | doi: 10.1007/s00439-010-0798-3 issn: 0340-6717 e-issn: 1432-1203 |
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