English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/111156
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

CuO/SiO2 as a simple, effective and recoverable catalyst for alkylation of indole derivatives with diazo compounds

AuthorsFraile, José M. ; Jeune, Karel le; Mayoral, José A. ; Ravasio, Nicoletta; Zaccheria, Federica
Issue Date2013
PublisherRoyal Society of Chemistry (UK)
CitationOrganic and Biomolecular Chemistry 11(26): 4327-4332 (2013)
AbstractThe purely inorganic copper oxide on silica catalyzes the reaction of methyl phenyldiazoacetate with N-methyl indole under mild reaction conditions, giving the alkylation (formally a C-H insertion) in position 3, and the catalyst can be recovered and reused at least in 5 consecutive runs with only minor loss in activity. The scope of the reaction includes various diazo compounds and indole or pyrrole derivatives leading to alkylation or cyclopropanation depending on the heterocycle structure. An alternative mechanism, without reduction of Cu(ii) to Cu(i), is proposed on the basis of the obtained results. This journal is © The Royal Society of Chemistry 2013.
Publisher version (URL)http://dx.doi.org/10.1039/C3OB40264A
URIhttp://hdl.handle.net/10261/111156
DOI10.1039/C3OB40264A
Identifiersdoi: 10.1039/C3OB40264A
issn: 1477-0520
e-issn: 1477-0539
Appears in Collections:(ISQCH) Artículos
Files in This Item:
File Description SizeFormat 
diazocompoundspdf.pdf182,61 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.