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A new biocompatible and antibacterial phosphate free glass-ceramic for medical applications

AutorCabal, Belén ; Alou, Luis; Cafini, Fabio; Couceiro, Ramiro; Sevillano, David; Esteban-Tejeda, Leticia; Guitián, Francisco; Torrecillas, Ramón ; Moya, J. S.
Fecha de publicación2014
EditorNature Publishing Group
CitaciónScientific Reports 4: 5440 (2014)
ResumenIn the attempt to find valid alternatives to classic antibiotics and in view of current limitations in the efficacy of antimicrobial-coated or loaded biomaterials, this work is focused on the development of a new glass-ceramic with antibacterial performance together with safe biocompatibility. This bactericidal glass-ceramic composed of combeite and nepheline crystals in a residual glassy matrix has been obtained using an antimicrobial soda-lime glass as a precursor. Its inhibitory effects on bacterial growth and biofilm formation were proved against five biofilm-producing reference strains. The biocompatibility tests by using mesenchymal stem cells derived from human bone indicate an excellent biocompatibility.
DescripciónThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License.
Versión del editorhttp://dx.doi.org/10.1038/srep05440
Identificadoresdoi: 10.1038/srep05440
issn: 2045-2322
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