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Título: | The benefit of DNA supercoiling during replication |
Autor: | Schvartzman, Jorge Bernardo CSIC ORCID ; Martínez-Robles, María Luisa CSIC; Hernandez, Pablo CSIC ; Krimer, Dora B. CSIC ORCID | Palabras clave: | DNA topology DNA replication Supercoiling Catenanes Knots Topoisomerases |
Fecha de publicación: | 2013 | Editor: | Portland Press | Citación: | Biochemical Society Transactions 41 (646-651) | Resumen: | DNA topology changes dynamically during DNA replication. Supercoiling, precatenation, catenation and knotting interplay throughout the process that is finely regulated by DNA topoisomerases. Here we present an overview of theoretical and experimental approaches to understand the interplay between various manifestations of topological constraints acting on replicating DNA molecules. Discussed data reveal that DNA entanglements (supercoils and catenanes) play an active role in preventing the formation of deleterious knots. | Descripción: | 16 p.-3 fig. | Versión del editor: | http://dx.doi.org/10.1042/BST20120281 | URI: | http://hdl.handle.net/10261/110579 | DOI: | 10.1042/BST20120281 | ISSN: | 0300-5127 | E-ISSN: | 1470-8752 |
Aparece en las colecciones: | (CIB) Artículos |
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Schvartzman_BiochSocTrans-2013.pdf | 325 kB | Adobe PDF | Visualizar/Abrir |
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