Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/110067
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Snail1 expression is required for sarcomagenesis |
Autor: | Alba-Castellón, Lorena; Loubat, Jordina; Muñoz Terol, Alberto CSIC ORCID; Bonilla, Félix; Casal, J. Ignacio CSIC ORCID ; García de Herreros, Antonio CSIC ORCID | Fecha de publicación: | may-2014 | Editor: | Elsevier | Citación: | Neoplasia 16(5): 413–421 (2014) | Resumen: | Snail1 transcriptional repressor is a major inducer of epithelial-to mesenchymal transition but is very limitedly expressed in adult animals. We have previously demonstrated that Snail1 is required for the maintenance of mesenchymal stem cells (MSCs), preventing their premature differentiation. Now, we show that Snail1 controls the tumorigenic properties of mesenchymal cells. Increased Snail1 expression provides tumorigenic capabilities to fibroblastic cells; on the contrary, Snail1 depletion decreases tumor growth. Genetic depletion of Snail1 in MSCs that are deficient in p53 tumor suppressor downregulates MSC markers and prevents the capability of these cells to originate sarcomas in immunodeficient SCID mice. Notably, an analysis of human sarcomas shows that, contrarily to epithelial tumors, these neoplasms display high Snail1 expression. This is particularly clear for undifferentiated tumors, 9which are associated with poor outcome. Together, our results indicate a role for Snail1 in the generation of sarcomas. | Descripción: | Under a Creative Commons license.-- et al. | Versión del editor: | http://dx.doi.org/10.1016/j.neo.2014.05.002 | URI: | http://hdl.handle.net/10261/110067 | DOI: | 10.1016/j.neo.2014.05.002 | ISSN: | 1522-8002 | E-ISSN: | 1476-5586 |
Aparece en las colecciones: | (IIBM) Artículos (CIB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Neoplasia 2014, 16 (5) 413-421 J. Ignacio Casal.pdf | 3,48 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
15
checked on 23-abr-2024
SCOPUSTM
Citations
25
checked on 23-abr-2024
WEB OF SCIENCETM
Citations
24
checked on 23-feb-2024
Page view(s)
301
checked on 24-abr-2024
Download(s)
292
checked on 24-abr-2024