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Title

N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

AuthorsBautista-Aguilera, Oscar M.; Samadi, Abdelouahid ; Chioua, Mourad ; Nikolic, K.; Filipic, S.; Agbaba, Danica; Soriano, Elena ; Andrés, L. de; Rodríguez-Franco, María Isabel ; Alcaro, S.; Ramsay, R. R.; Ortuso, F.; Yáñez, Matilde; Marco-Contelles, José
Issue Date2014
PublisherAmerican Chemical Society
CitationJournal of Medicinal Chemistry 57: 10455-10463 (2014)
AbstractOn the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.
URIhttp://hdl.handle.net/10261/109579
DOI10.1021/jm501501a
Identifiersdoi: 10.1021/jm501501a
issn: 0022-2623
e-issn: 1520-4804
Appears in Collections:(IQM) Artículos
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