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Título: | N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor |
Autor: | Bautista-Aguilera, Óscar M. CSIC ORCID; Samadi, Abdelouahid CSIC ORCID; Chioua, Mourad CSIC ORCID ; Nikolic, K.; Filipic, S.; Agbaba, Danica; Soriano, Elena CSIC; Andrés, Lucía de CSIC; Rodríguez-Franco, María Isabel CSIC ORCID ; Alcaro, S.; Ramsay, R. R.; Ortuso, F.; Yáñez, Matilde; Marco-Contelles, José CSIC ORCID | Fecha de publicación: | 2014 | Editor: | American Chemical Society | Citación: | Journal of Medicinal Chemistry 57: 10455-10463 (2014) | Resumen: | On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor. | URI: | http://hdl.handle.net/10261/109579 | DOI: | 10.1021/jm501501a | Identificadores: | doi: 10.1021/jm501501a issn: 0022-2623 e-issn: 1520-4804 |
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