Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/109558
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

An Extracellular Serine/Threonine-Rich Protein from Lactobacillus plantarum NCIMB 8826 Is a Novel Aggregation-Promoting Factor with Affinity to Mucin

AutorHevia, Arancha CSIC; Martínez Álvarez, Noelia CSIC ORCID; Ladero Losada, Víctor Manuel CSIC ORCID ; Álvarez González, Miguel Ángel CSIC ORCID ; Margolles Barros, Abelardo CSIC ORCID; Sánchez García, Borja CSIC ORCID
Fecha de publicaciónoct-2013
EditorAmerican Society for Microbiology
CitaciónApplied and Environmental Microbiology 79(19): 6059-6066 (2013)
ResumenAutoaggregation in lactic acid bacteria is directly related to the production of certain extracellular proteins, notably, aggregation- promoting factors (APFs). Production of aggregation-promoting factors confers beneficial traits to probiotic-producing strains, contributing to their fitness for the intestinal environment. Furthermore, coaggregation with pathogens has been proposed to be a beneficial mechanism in probiotic lactic acid bacteria. This mechanism would limit attachment of the pathogen to the gut mucosa, favoring its removal by the human immune system. In the present paper, we have characterized a novel aggregation- promoting factor in Lactobacillus plantarum. A mutant with a knockout of the D1 gene showed loss of its autoaggregative phenotype and a decreased ability to bind to mucin, indicating an adhesion role of this protein. In addition, heterologous production of the D1 protein or an internal fragment of the protein, characterized by its abundance in serine/threonine, strongly induced autoaggregation in Lactococcus lactis. This result strongly suggested that this internal fragment is responsible for the bioactivity of D1 as an APF. To our knowledge, this is the first report on a gene coding for an aggregation-promoting factor in Lb. plantarum. ©2013, American Society for Microbiology.
URIhttp://hdl.handle.net/10261/109558
DOI10.1128/AEM.01657-13
Identificadoresdoi: 10.1128/AEM.01657-13
issn: 0099-2240
e-issn: 1098-5336
Aparece en las colecciones: (IPLA) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

PubMed Central
Citations

12
checked on 04-mar-2024

SCOPUSTM   
Citations

25
checked on 16-mar-2024

WEB OF SCIENCETM
Citations

23
checked on 27-feb-2024

Page view(s)

328
checked on 18-mar-2024

Download(s)

107
checked on 18-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.