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Alimentómica y metabolómica de Alzheimer y cáncer. Primeros pasos hacia la alimentación del futuro

Other TitlesNew results on foodomics investigations of cancer and metabolomics of alzheimer
AuthorsValdés, Alberto ; Ibáñez, Clara ; García-Cañas, Virginia ; Herrero, Miguel ; Ibáñez, Elena ; Simó, Carolina ; Cifuentes, Alejandro
Issue Date2014
AbstractSafety, quality and bioactivity of foods and food ingredients are investigated in Foodomics through the application and integration of advanced omics technologies, including genomics, transcriptomics, proteomics and/or metabolomics. The main goals of Foodomics are to improve consumers' well-being and knowledge. In this seminar, we will present some of the latest Foodomics results obtained in our laboratory. Namely, these Foodomics works were done: I) to investigate the possibilities of Foodomics in Alzheimer's disease studies and, II) to determine the anti-proliferative effect of food ingredients against different human cancer cell lines. Wholetranscriptome microarray, proteomics and MS-based non-targeted whole-metabolome approaches were employed to carry out the mentioned studies. These Foodomics strategies enabled: I) the identification of biomarkers for early detection of Alzheimer's disease which should allow to investigate the effect of diet on this illness, and II) the identification of several differentially expressed genes alone and/or linked to changed metabolic pathways that were modulated by food ingredients in cancer cells, providing new evidences at molecular level on the antiproliferative effect of food compounds.
DescriptionTrabajo presentado al XV Congreso Latinoamericano de Cromatografía y Técnicas Afines y VII Congreso Colombiano de Cromatografía celebrados en Cartagena de Indias (Colombia) del 29 de septiembre al 3 de octubre de 2014.
Publisher version (URL)http://colacro2014.com/
Appears in Collections:(CIAL) Comunicaciones congresos
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