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Closed Access item Estrogenic activity associated with organochlorine compounds in fish extracts from European mountain lakes
Grimalt, Joan O.
Fernández Ramón, M. Pilar
|Keywords:||Estrogenic activity, Fish, High mountains, Organochlorine compounds, Long-range pollution transport|
|Citation:||Environmental Pollution 145(3): 745-752 (2007)|
|Abstract:||Fish muscle extracts from ten European mountain lakes were analyzed for organochlorine compounds (OCs) and estrogenic activity, the latter by a recombinant yeast assay based on the human estrogen receptor. Seventy percent of the samples showed estrogenic activity above detection limits and a subset of five samples showed estrogenic activities, equivalent to more than 10,000 pg/g of estradiol. These highly estrogenic samples occurred in two lakes, Velké Hinçovo in the Tatra Mountains and Redon in the Pyrenees. Principal component analysis correlated estrogenic activity of muscle extracts to fish age and concentrations of the more chlorinated polychlorobiphenyls (PCBs). This is consistent with previously observed correlations of these PCBs with fish age. In addition, most fish with high estrogenic activity were found in lakes containing high OC
levels in the sediments, which gives further ground to atmospheric deposition of anthropogenic pollutants as main process leading to the observed endocrine disruption effects.|
Estrogen receptor agonists in lake fish are correlated with organochlorine compound content.
|Description:||8 pages, 3 figures, 5 tables.-- PMID: 16997436 [PubMed].-- Online version available Sep 25, 2006.|
Issue title: Ozone at the Intensive Monitoring Plots in SW Europe.
|Publisher version (URL):||http://dx.doi.org/10.1016/j.envpol.2006.05.021|
|Appears in Collections:||(IBMB) Artículos|
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