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Closed Access item Hepatic marker enzymes, biochemical parameters and pathological effects in lambs experimentally infected with Dicrocoelium dendriticum (Digenea)

Authors:Manga-González, M. Yolanda
Ferreras, Mª del Carmen
Campo, Raquel
González Lanza, Camino
Pérez Pérez, Valentín
García Marín, Juan Francisco
Keywords:León Province, Mast-cells, NW Spain, Sheep, Liver, Dicroceliosis, Histopathology, Fascioliasis, Elimination, Prevalence
Issue Date:2004
Citation:Parasitology Research 93(5): 344-355 (2004)
Abstract:Hepatic enzymes and biochemical parameter values were analysed in the sera of 32 lambs: 12 infected with 1,000 Dicrocoelium dendriticum metacercariae, 12 with 3,000 and eight controls. Blood samples were collected at intervals of 30 days from day 0 post-infection (p.i.). Half the lambs in each group were slaughtered on days 60 and 180 p.i, respectively. A histopathological and ultrastructural study was carried out on the liver, gall bladder and hepatic lymph nodes of all animals. A minute increase was detected in the bilirubin (7%) and albumin (3%) values in the infected lambs (with 30–2,063 worms) in comparison with those of the controls. The hepatic enzyme values did increase, above all aspartate aminotransferase (19%) and alanine aminotransferase (22%), mainly in the lambs tested with 3,000 metacercariae (38% and 48%, respectively). The increase was significant 60 days p.i. The severity of the lesions was closely associated with the parasite burden.
Description:12 pages, 5 figures.-- PMID: 15197580 [PubMed].-- Available online 10 Jun 2004.
Publisher version (URL):http://dx.doi.org/10.1007/s00436-004-1128-2
Appears in Collections:(IGM) Artículos

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