Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/104669
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Mallorquí-Fernández, Goretti | - |
dc.contributor.author | Marrero, Aniebrys | - |
dc.contributor.author | García-Piqué, Sonia | - |
dc.contributor.author | García-Castellanos, Raquel | - |
dc.contributor.author | Gomis-Rüth, F. Xavier | - |
dc.contributor.author | Gomis-Rüth, F. Xavier | - |
dc.date.accessioned | 2014-11-07T11:13:35Z | - |
dc.date.available | 2014-11-07T11:13:35Z | - |
dc.date.issued | 2004-04-28 | - |
dc.identifier | doi: 10.1016/j.femsle.2004.04.035 | - |
dc.identifier | issn: 0378-1097 | - |
dc.identifier.citation | FEMS Microbiology Letters 235(1): 1-8 (2004) | - |
dc.identifier.uri | http://hdl.handle.net/10261/104669 | - |
dc.description.abstract | Globalisation has entailed a massive increase in trade and human mobility facilitating the rapid spread of infectious agents, including those that are drug resistant. A particularly serious threat to human health is posed by methicillin-resistant staphylococcal strains which have acquired molecular mechanisms to evade the action of β-lactam antibiotics (BLAs). Full expression of high-level methicillin resistance involves a complex network of molecules and depends primarily on sufficient expression of a penicillin-binding protein with low sensitivity towards BLAs. Other factors include the fine-tuned regulation of autolytic activity of cell-wall components, as well as an optimal rate of peptidoglycan precursor formation and a highly specific peptidoglycan precursor structure. Three-dimensional structural data are available on several of the pieces involved in the jigsaw puzzle and provide a molecular basis for the understanding of methicillin resistance and for the design of new therapeutic strategies. © 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.description.sponsorship | This study was supported by grants BIO2000-1659 and BIO2003-00132 from the Spanish Ministry for Science and Technology. R.G.C. is recipient of an FPI Ph.D.-fellowship from the Spanish Ministry for Science and Technology. A.M. acknowledges a postgraduate fellowship from >Fundación Carolina>, Spanish Ministry of Foreign Affairs | - |
dc.publisher | Blackwell Publishing | - |
dc.rights | closedAccess | - |
dc.subject | DD, Dimerisation domain | - |
dc.subject | DBD, DNA-binding domain | - |
dc.subject | BLA, β-lactam antibiotic | - |
dc.subject | Methicillin | - |
dc.subject | X-ray crystal structure | - |
dc.subject | Staphylococcus aureus | - |
dc.subject | Three-dimensional structure | - |
dc.subject | Bacterial antibiotic resistance | - |
dc.subject | MRSA, Methicillin-resistant Staphylococcus aureus | - |
dc.subject | MSSA, Methicillin-susceptible Staphylococcus aureus | - |
dc.subject | NPBD, Non-penicillin-binding domain | - |
dc.subject | PBP, Penicillin-binding protein | - |
dc.title | Staphylococcal methicillin resistance: Fine focus on folds and functions | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.femsle.2004.04.035 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.femsle.2004.04.035 | - |
dc.date.updated | 2014-11-07T11:13:35Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
Aparece en las colecciones: | (IBMB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
21
checked on 24-mar-2024
WEB OF SCIENCETM
Citations
16
checked on 26-feb-2024
Page view(s)
382
checked on 23-abr-2024
Download(s)
114
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.