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Effects of PipX on NtcA-dependent promoters and characterization of the cox3 promoter region in the heterocyst-forming cyanobacterium Anabaena sp. PCC 7120

AuthorsCamargo, Sergio ; Valladares, Ana ; Forchhammer, K.; Herrero, Antonia
Transcriptional regulation
Issue Date2014
CitationFEBS Letters 588: 1787- 1794 (2014)
AbstractIn Anabaena, the pipX gene is induced in the cells differentiating into heterocysts, being the PipX factor required for full expression of late heterocyst-specific genes. Here we show that PipX has a positive effect on in vitro binding of the transcription factor NtcA to DNA, as well as on transcript production, in different NtcA-dependent promoters. We found that the cox3 operon, encoding a heterocyst-specific terminal respiratory oxidase, is expressed from three nitrogen-regulated promoters to which NtcA binds. At the three sites, NtcA binding is potentiated by PipX. Thus, PipX has a direct effect on gene expression influencing the activity of NtcA.
Identifiersdoi: 10.1016/j.febslet.2014.03.039
issn: 1873-3468
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