English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/103277
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Toxicity induced by chemical warfare agents: Insights on the protective role of melatonin

AuthorsPita, Rene; Marco-Contelles, José ; Ramos, Eva; Pino, Javier del; Romero, Alejandro
KeywordsToxicity
Free radicals
Melatonin
Chemical warfare agents
Neuroprotection
Issue Date2013
PublisherElsevier
CitationChemico-Biological Interactions 206: 134- 142 (2013)
AbstractChemical Warfare Agents (CWAs) are substances that can be used to kill, injure or incapacitate an enemy in warfare, but also against civilian population in terrorist attacks. Many chemical agents are able to generate free radicals and derived reactants, excitotoxicity process, or inflammation, and as consequence they can cause neurological symptoms and damage in different organs. Nowadays, taking into account that total immediate decontamination after exposure is difficult to achieve and there are not completely effective antidotes and treatments against all CWAs, we advance and propose that medical countermeasures against CWAs poisoning would benefit from a broad-spectrum multipotent molecule. Melatonin, a versatile and ubiquitous antioxidant molecule, originally discovered as a hormone synthesized mainly in the pineal gland, has low toxicity and high efficacy in reducing oxidative damage, anti-inflammatory effects by regulation of multiple cellular pathways and properties to prevent excitotoxicity, among others. The purpose of this review is to show the multiple and diverse properties of melatonin, as a pleiotropic indole derivative, and its marked potential for improving human health against the most widely used chemical weapons.
URIhttp://hdl.handle.net/10261/103277
DOI10.1016/j.cbi.2013.09.001
Identifiersdoi: 10.1016/j.cbi.2013.09.001
issn: 0009-2797
e-issn: 1872-7786
Appears in Collections:(IQM) Artículos
(IQOG) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.