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Osteoprotegerin CGA haplotype protection against cerebrovascular complications in anti-CCP negative patients with rheumatoid arthritis

AuthorsGenre, Fernanda; López-Mejías, Raquel; García-Bermúdez, Mercedes; Castañeda, Santos; González-Juanatey, Carlos; Llorca, Javier; Corrales, Alfonso; Ubilla, Begoña; Miranda-Filloy, J. A.; Pina, Trinitario; Gómez-Vaquero, C.; Rodríguez-Rodríguez, Luis; Fernández-Gutiérrez, B.; Balsa, Alejandro; Pascual-Salcedo, Dora; López-Longo, Francisco Javier; Carreira, Patricia E.; Blanco, Ricardo; González-Álvaro, I.; Martín, J.; González-Gay, M. A.
Issue Date2014
PublisherPublic Library of Science
CitationPLoS ONE 9 (2014)
Abstract© 2014 Genre et al. Introduction: Rheumatoid arthritis is an inflammatory disease with high incidence of cardiovascular disease due to accelerated atherosclerosis. Osteoprotegerin (OPG) has been associated with increased risk of atherosclerotic disease in the general population. Several polymorphisms in the OPG gene with functional effects on cardiovascular disease in nonrheumatic individuals have been described. Therefore, we aimed to analyze the effect of three of these functional OPG polymorphisms on the risk of cardiovascular disease in a large and well-characterized cohort of Spanish patients with rheumatoid arthritis.
Identifiersdoi: 10.1371/journal.pone.0106823
issn: 1932-6203
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