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| Título: | Orchestration of floral initiation by APETALA1 |
Autor: | Kaufmann, Kerstin; Ferrier, Thilia CSIC ORCID; Serrano Mislata, Antonio CSIC ORCID; Madueño Albi, Francisco CSIC ORCID; Riechmann, José Luis CSIC ORCID | Fecha de publicación: | 2-abr-2010 | Editor: | American Association for the Advancement of Science | Citación: | Science 328(5974): 85-89 (2010) | Resumen: | The MADS-domain transcription factor APETALAl (AP1) is a key regulator of Arabidopsis flower development. To understand the molecular mechanisms underlying AP1 function, we identified its target genes during floral initiation using a combination of gene expression profiling and genome-wide binding studies. Many of its targets encode transcriptional regulators, including known floral repressors. The latter genes are down-regulated by AP1, suggesting that it initiates floral development by abrogating the inhibitory effects of these genes. Although AP1 acts predominantly as a transcriptional repressor during the earliest stages of flower development, at more advanced stages it also activates regulatory genes required for floral organ formation, indicating a dynamic mode of action. Our results further imply that AP1 orchestrates floral initiation by integrating growth, patterning, and hormonal pathways. | Descripción: | Kaufmann, Kerstin et al. | URI: | http://hdl.handle.net/10261/101903 | DOI: | 10.1126/science.1185244 | Identificadores: | doi: 10.1126/science.1185244 issn: 0036-8075 e-issn: 1095-9203 |
| Aparece en las colecciones: | (IBMCP) Artículos (CRAG) Artículos |
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| accesoRestringido.pdf | 15,38 kB | Adobe PDF |  Visualizar/Abrir |
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