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dc.contributor.authorCueva, Carolina-
dc.contributor.authorMuñoz-González, Irene-
dc.contributor.authorBustos, Irene-
dc.contributor.authorRequena, Teresa-
dc.contributor.authorCampo, Rosa del-
dc.contributor.authorMartín-Álvarez, Pedro J.-
dc.contributor.authorBartolomé, Begoña-
dc.contributor.authorMoreno-Arribas, M. Victoria-
dc.date.accessioned2014-08-26T12:07:58Z-
dc.date.available2014-08-26T12:07:58Z-
dc.date.issued2012-
dc.identifierdoi: 10.1111/j.1472-765X.2012.03248.x-
dc.identifierissn: 0266-8254-
dc.identifiere-issn: 1472-765X-
dc.identifier.citationLetters in Applied Microbiology 54(6): 557-563 (2012)-
dc.identifier.urihttp://hdl.handle.net/10261/101229-
dc.description.abstract[Aims]: To investigate the effect of seven wine phenolic compounds and six oenological phenolic extracts on the growth of pathogenic bacteria associated with respiratory diseases (Pseudomonas aeruginosa, Staphylococcus aureus, Moraxella catarrhalis, Enterococcus faecalis, Streptococcus sp Group F, Streptococcus agalactiae and Streptococcus pneumoniae). [Methods and Results]: Antimicrobial activity was determined using a microdilution method and quantified as IC 50. Mor. catarrhalis was the most susceptible specie to phenolic compounds and extracts. Gallic acid and ethyl gallate were the compounds that showed the greatest antimicrobial activity. Regarding phenolic extracts, GSE (grape seed extract) and GSE-O (oligomeric-rich fraction from GSE) were the ones that displayed the strongest antimicrobial effects. [Conclusions]: Results highlight the antimicrobial properties of wine phenolic compounds and oenological extracts against potential respiratory pathogens. The antimicrobial activity of wine phenolic compounds was influenced by the type of phenolic compounds. Gram-negative bacteria were more susceptible than Gram-positive bacteria to the action of phenolic compounds and extracts; however, the effect was species-dependent. [Significance and Impact of Study]: The ability to inhibit the growth of respiratory pathogenic bacteria as shown by several wine phenolic compounds and oenological extracts warrants further investigations to explore the use of grape and wine preparations in oral hygiene. © 2012 The Authors. Letters in Applied Microbiology © 2012 The Society for Applied Microbiology.-
dc.description.sponsorshipThis research was supported by the Spanish Ministry for Science and Innovation (AGL2009-13361-C02-00, AGL2010-17499, AGL2006-04514 and CSD2007-00063 Consolider Ingenio 2010 FUN-C-FOOD Projects) and the Comunidad de Madrid (ALIBIRD P2009 ⁄ AGR-1469 Project). C.C. is the recipient of fellowships from the FPI-MICINN programme. R.d.C. has a Miguel Servet contract (CB05 ⁄ 137) from the Instituto Nacional de Salud Carlos III-FIS.-
dc.publisherJohn Wiley & Sons-
dc.relationS2009/AGR-1469/ALIBIRD-
dc.rightsclosedAccess-
dc.subjectPhenolic compounds-
dc.subjectPhenolic extracts-
dc.subjectRespiratory pathogenic bacteria-
dc.subjectWine-
dc.subjectAntimicrobial activity-
dc.titleAntibacterial activity of wine phenolic compounds and oenological extracts against potential respiratory pathogens-
dc.typeartículo-
dc.identifier.doi10.1111/j.1472-765X.2012.03248.x-
dc.date.updated2014-08-26T12:07:58Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderComunidad de Madrid-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)-
dc.contributor.funderInstituto de Salud Carlos III-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100012818es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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