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Title

Alternative splicing variants of proinsulin mRNA and the effects of excess proinsulin on cardiac morphogenesis

AuthorsMartínez-Campos, Enrique; Hernández-SanMiguel, Esther; López-Sánchez, Carmen; Pablo, Flora de ; Hernández-Sánchez, Catalina
KeywordsProinsulin
Insulin gene
Alternative splicing
Intron retention
Cardiogenesis
Cardiac malformation
Issue Date6-Jun-2013
PublisherElsevier
CitationFEBS Letters 587 (2013) 2272–2277
AbstractAlternative forms of proinsulin mRNA with differential translational capacities and unknown significance are expressed in several developing tissues and in the adult pancreas. In the chick embryo developing heart, we observed low expression of the translationally active transcript of embryonic proinsulin (Pro1B), and predominant expression of the intron 1-unspliced variant, translationally inactive. In the embryonic mouse heart, intron 1-unspliced isoform appeared after E12.5. This tight regulation is required for normal development, since overexpression of Pro1B resulted in abnormal cardiac morphogenesis in 40% of chick embryos, and was accompanied by changes in gene expression of Amhc1and Vmhc1.
Description31 p.-5 fig.-mat.sup.
Publisher version (URL)http://dx.doi.org/10.1016/j.febslet.2013.05.060
URIhttp://hdl.handle.net/10261/101069
DOI10.1016/j.febslet.2013.05.060
ISSN0014-5793
E-ISSN1873-3468
Appears in Collections:(CIB) Artículos
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