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Title

Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic

AuthorsRibeiro-Viana, Renato ; Bonechi, Elena; Rojo, Javier ; Ballerini, Clara; Comito, Giuseppina; Richichi, Barbara; Nativi, Cristina
Issue Date2014
PublisherBeilstein-Institut zur Förderung der Chemischen Wissenschaften
CitationBeilstein Journal of Organic Chemistry, 10: 1317-1324 (2014)
AbstractVaccination strategies based on dendritic cells (DCs) armed with specific tumor antigens have been widely exploited due the properties of these immune cells in coordinating an innate and adaptive response. Here, we describe the convergent synthesis of the bifunctional multivalent glycodendron 5, which contains nine residues of mannose for DC targeting and one residue of an immunogenic mimetic of a carbohydrate melanoma associated antigen. The immunological assays demonstrated that the glycodendron 5 is able to induce human immature DC activation in terms of a phenotype expression of co-stimulatory molecules expression and MHCII. Furthermore, DCs activated by the glycodendron 5 stimulate T lymphocytes to proliferate in a mixed lymphocytes reaction (MLR).
Publisher version (URL)http://dx.doi.org/10.3762/bjoc.10.133
URIhttp://hdl.handle.net/10261/101024
DOI10.3762/bjoc.10.133
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