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Título: | Activation of RANKL-induced osteoclasts and memory T lymphocytes by Porphyromonas gingivalis is serotype dependant |
Autor: | Vernal, Rolando; Díaz-Zúñiga, Jaime; Melgar-Rodríguez, Samanta; Pujol, Myriam; Díaz-Guerra, Eva CSIC; Silva, Augusto CSIC; Sanz, Mariano; García-Sanz, José A. CSIC ORCID | Palabras clave: | Porphyromonas gingivalis Serotypes T lymphocytes RANKL Bone resorption Periodontitis |
Fecha de publicación: | 1-may-2014 | Editor: | John Wiley & Sons | Citación: | Journal of Clinical Periodontology 41 (5) 451-459 | Resumen: | Aim: Destructive periodontitis is associated with a Th1-Th17-dominated immune response and the Porphyromonas gingivalis K1 and K2 serotypes induce a strong Th1-Th17 response. This study aimed to investigate whether these P. gingivalis serotypes were associated with bone resorption and periodontitis. Materials and Methods: The RANKL production and TRAP+ osteoclast induction were quantified when naïve-T-lymphocytes were stimulated with dendritic cells primed with the P. gingivalis serotypes. The T-bet, GATA-3, RORC2, and Foxp3 expression was correlated with RANKL production. The frequency of proliferating memory-Tlymphocytes in response to P. gingivalis serotypes was determined in both periodontitis and healthy subjects. Results: T-lymphocytes stimulated by K1 or K2-primed dendritic cells elicited higher levels of RANKL and TRAP+ osteoclasts than cells stimulated with the other serotypes. RANKL positively correlated with RORC2. Upon K1 or K2 stimulation, higher frequency of responding memory-T-lymphocytes was detected in periodontitis patients than controls. Upon K4 or K- stimulation, higher frequency of responding memory-Tlymphocytes was detected in healthy subjects. Conclusions: P. gingivalis serotypes K1 and K2 are associated with bone resorption through the increased RANKL production and TRAP+ osteoclast induction. Due to their association with higher frequency of memory-T-lymphocytes in periodontitis patients, these serotypes could be involved in the pathogenesis of periodontitis. | Descripción: | 35 p.-2 tab.-4 fig.Este artículo no presenta el mismo título en el preprint adjunto ("Porphyromonas gingivalis K1 and K2 serotypes are associated with periodontitis") | Versión del editor: | http://dx.doi.org/10.1111/jcpe.12236 | URI: | http://hdl.handle.net/10261/100367 | DOI: | 10.1111/jcpe.12236 | ISSN: | 0303-6979 | E-ISSN: | 1600-051X |
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Vernal et al (2014) JClinPeriodontol41(5)451-459.pdf | 669,51 kB | Adobe PDF | Visualizar/Abrir |
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