English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/100268
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Resistance of casein-derived bioactive peptides to simulated gastrointestinal digestion

AuthorsContreras, María del Mar; Sánchez, David ; Sevilla, Mª Ángeles; Recio, Isidra ; Amigo, Lourdes
Issue Date2013
PublisherElsevier
CitationInternational Dairy Journal 32(2): 71-78 (2013)
AbstractThe resistance of six casein-derived peptides, including antihypertensive peptides RYLGY, AYFYPEL and YQKFPQY, to simulated gastrointestinal digestion and the effect on angiotensin-converting enzyme (ACE)-inhibitory activity were evaluated. After digestion, peptides RYLGY, AYFYPEL, and YQKFPQY were partly hydrolysed by the digestive enzymes. RYLGY and AYFYPEL maintained potent ACE-inhibitory activity, with IC50 values as low as 9.3 and 4.7μgmL-1, respectively. Digestion fragments were sequenced and then synthesised to evaluate their activity. Several showed potent ACE-inhibitory activity, which could explain the invitro activity of the digests. A notable antioxidant activity was also observed. Since AYFYPEL was less susceptible to digestion, we focused on the antihypertensive activity in spontaneously hypertensive rats of the main digestion fragments of RYLGY. Interestingly, these peptides showed moderate effects invivo. This suggests that the undigested fraction could also contribute to the invivo effects of RYLGY and AYFYPEL, and other minor fragments may also participate. © 2013 Elsevier Ltd.
Publisher version (URL)http://dx.doi.org/10.1016/j.idairyj.2013.05.008
URIhttp://hdl.handle.net/10261/100268
DOI10.1016/j.idairyj.2013.05.008
Identifiersdoi: 10.1016/j.idairyj.2013.05.008
issn: 0958-6946
e-issn: 1879-0143
Appears in Collections:(CIAL) Artículos
Files in This Item:
File Description SizeFormat 
Resistance of caseins.pdf126,88 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.