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Title

Peptidomic study of Spanish blue cheese (Valdeón) and changes after simulated gastrointestinal digestion

AuthorsSánchez-Rivera, Laura ; Diezhandino, Isabel; Gómez-Ruiz, José Ángel ; Fresno, José María; Miralles, Beatriz ; Recio, Isidra
KeywordsPeptidomics
Active peptide
Valdeón cheese
MS/MS
Gastrointestinal digestion
Issue Date2014
PublisherWiley-VCH
CitationElectrophoresis 35(11): 1627-1636 (2014)
AbstractIt is increasingly evident that digestion can affect the biological activity of cheese by the release of new active peptides from their precursors or, on the contrary, giving rise to fragments without activity. The characterization of the peptidome of a Spanish blue cheese, Valdeón, has been conducted before and after gastrointestinal digestion, and the digests have been compared to those obtained from pasteurized skimmed milk powder (SMP) using a bioinformatics platform. Peptidomic profiling of digests revealed several regions that are especially resistant to digestion (among them β-casein 60-93, 128-140, and 193-209). Some of them correspond to well-conserved regions between species (human, cow, sheep, and goat) and include peptide sequences with reported bioactivity. The great peptide homology found between both digests, cheese and SMP, suggests that the gastrointestinal digestion could bring closer the profile of products with different proteolytic state. Although most of the biologically active peptides found in cheese after digestion were also present in SMP digest, there were some exceptions that can be attributed to the absence of the relevant precursor peptide before digestion. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
URIhttp://hdl.handle.net/10261/100218
DOI10.1002/elps.201300510
Identifiersdoi: 10.1002/elps.201300510
e-issn: 1522-2683
issn: 0173-0835
Appears in Collections:(CIAL) Artículos
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