English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/100134
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Long-term effect of an aqueous Fraxinus excelsior L. seed extract in spontaneously hypertensive rats

AuthorsLópez-Carreras, Noemi; Fernández-Vallinas, Sandra; Miguel, Marta ; Aleixandre, Amaya
Issue Date2014
PublisherHindawi Publishing Corporation
CitationInternational Journal of Hypertension: 565212 (2014)
AbstractThe effect of long-term intake of different doses (20, 40, and 60 mg/kg/day) of a Fraxinus excelsior L. seed extract (FESE) on spontaneously hypertensive rats (SHR) was evaluated. Water was used as control and captopril (50 mg/kg/day) was used as positive control. Systolic blood pressure, body weight, and food and liquid intake were registered weekly in SHR. The antioxidant and vascular relaxing properties of FESE were also studied in these animals. The development of hypertension was attenuated in the groups treated with captopril or FESE. The antihypertensive effect was more accentuated in the captopril group than in the FESE groups, and it was paradoxically more accentuated in the groups treated with 20 mg/kg/day or 40 mg/kg/day of FESE than in the group treated with the highest dose of this extract. Body weight gain and food intake increased in the FESE groups. After removing the corresponding antihypertensive treatment, the arterial blood pressure and the body weight of the FESE treated animals returned to control values. In addition, FESE increased plasma antioxidant capacity and decreased plasma and liver malondialdehyde levels. Moreover, acetylcholine relaxation improved in the aorta rings from the FESE treated rats. © 2014 Noemi López-Carreras et al.
DescriptionThis is an open access article distributed under the Creative Commons Attribution License.
Publisher version (URL)http://dx.doi.org/10.1155/2014/565212
Identifiersdoi: 10.1155/2014/565212
issn: 2090-0384
e-issn: 2090-0392
Appears in Collections:(CIAL) Artículos
Files in This Item:
File Description SizeFormat 
Long-Term Effect of an Aqueous.pdf1,69 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.