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http://hdl.handle.net/10261/81
2024-03-19T07:59:16ZNeuro-Gastro-Cannabinology: A Novel Paradigm for Regulating Mood and Digestive Health
http://hdl.handle.net/10261/348988
Título: Neuro-Gastro-Cannabinology: A Novel Paradigm for Regulating Mood and Digestive Health
Autor: Turco, F.; Brugnatelli, V.; Abalo, Raquel
Resumen: The maintenance of homeostasis in the gastrointestinal (GI) tract is ensured by the presence of the endocannabinoid system (ECS), which regulates important physiological activities, such as motility, permeability, fluid secretion, immunity, and visceral pain sensation. Beside its direct effects on the GI system, the ECS in the central nervous system indirectly regulates GI functions, such as food intake and energy balance. Mounting evidence suggests that the ECS may play an important role in modulating central neurotransmission which affects GI functioning. It has also been found that the interaction between the ECS and microbiota affects brain and gut activity in a bidirectional manner, and a number of studies demonstrate that there is a strong relationship between GI dysfunctions and mood disorders. Thus, microbiota can regulate the tone of the ECS. Conversely, changes in intestinal ECS tone may influence microbiota composition. In this mini-review, we propose the concept of neuro-gastro-cannabinology as a novel and alternative paradigm for studying and treating GI disorders that affect mood, as well as mood disorders that imbalance GI physiology. This concept suggests the use of prebiotics or probiotics for improving the tone of the ECS, as well as the use of phytocannabinoids or endocannabinoid-like molecules, such as palmitoylethanolamide, to restore the normal intestinal microbiota. This approach may be effective in ameliorating the negative effects of GI dysfunctions on mood and/or the effects of mood disorders on digestive health.2024-03-01T13:00:13ZDevelopment of hybrid hierarchical coatings on Mg3Zn0.4Ca alloy for orthopaedic implants
http://hdl.handle.net/10261/348726
Título: Development of hybrid hierarchical coatings on Mg3Zn0.4Ca alloy for orthopaedic implants
Autor: Moreno, L.; Mohedano, Marta; Arrabal, Raúl; Rodríguez-Hernández, Juan; Matykina, Endzhe
Resumen: A hybrid hierarchical coating (HHC) biodegradable system, consisting of a ceramic (PEO) and a biodegradable microporous polymeric (PLA or PCL) layers, was developed on Mg3Zn0.4Ca alloy and evaluated under quasi-in vivo conditions. The polymer top-coat was produced using the Breath Figures approach by dip-coating the PEO treated ceramic surface onto a PLA/PCL polymer solution and withdraw under high relative humidity. According to our findings, when the polymer coating is applied directly onto the PEO layer using high humidity a negligible corrosion protection was observed. However, this issue was overcome by first applying a thin sealing polymer layer before the microporous polymer layer prepared by dip-coating in the absence of moisture. The HHC system improves the corrosion resistance by 10–12 times compared to the stand-alone PEO coating and, due to its inherent porosity, should be amenable for further functionalization with pharmaceutical agents.2024-02-29T08:20:25Z¿qué sabemos de? La Nanomedicina
http://hdl.handle.net/10261/348192
Título: ¿qué sabemos de? La Nanomedicina
Autor: Herranz, Fernando
Resumen: La nanomedicina, entendida como la aplicación de la nanotecnología a problemas biomédicos, es un campo de investigación relativamente nuevo que presenta múltiples aplicaciones, desde el diagnóstico hasta el tratamiento de patologías como el cáncer, enfermedades cardiovasculares e incluso infecciosas. Su estudio cubre disciplinas como la química para preparar los nuevos nanomateriales, la física para caracterizar sus propiedades y la biomedicina para la aplicación final, sin olvidar aspectos de ingeniería o bioética; en este sentido, la nanomedicina se extiende desde la investigación básica hasta la aplicación en clínica. Una de sus aplicaciones más espectaculares y recientes es la vacuna frente a la COVID-19, basadas en nanopartículas lipídicas que transporta el ARN mensajero. Este libro trata desde las bases fisicoquímicas que hacen diferente a la nanomedicina hasta las principales aplicaciones en diagnóstico y terapia. El uso futuro de los nanomateriales en biomedicina ofrece un mundo inmenso por explorar.2024-02-23T12:10:03ZRecent progress in antivirals against zika virus
http://hdl.handle.net/10261/348055
Título: Recent progress in antivirals against zika virus
Autor: Peréz-Pérez, María-Jesús; Priego, Eva María; Martín-Acebes, Miguel A.2024-02-22T13:30:02Z