2024-03-29T04:56:23Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/578902021-11-22T12:51:01Zcom_10261_64com_10261_1col_10261_317
Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for multiple sclerosis
Alcina, Antonio
Fernández, Óscar
González, Juan Ramón
Catalá-Rabasa, Antonio
Fedetz, María
Ndagire, D.
Leyva, Laura
Guerrero, Miguel
Arnal, Carmen
Delgado, Concepción
Lucas, Miguel
Izquierdo, Guillermo
Matesanz, F.
A recent genome-wide association study conducted by the International Multiple Sclerosis Genetic Consortium (IMSGC) identified, among others, a number of putative multiple sclerosis (MS) susceptibility variants at position 1p22. Twenty-one SNPs positively associated with MS were located at the GFI-EVI5-RPL5-FAM69A locus. In this study, we performed an analysis and fine mapping of this locus, genotyping eight Tag-SNPs in 732 MS patients and 974 controls from Spain. We observed an association with MS in three of eight Tag-SNPs: rs11804321 (P=0.008, OR=1.29; 95% CI1.08-1.54), rs11808092 (P=0.048, OR=1.19; 95% CI1.03-1.39) and rs6680578 (P=0.0082, OR=1.23; 95% CI1.07-1.41). After correcting for multiple comparisons and using logistic regression analysis to test the addition of each SNP to the most associated SNPs, we observed that rs11804321 alone was sufficient to model the association. This Tag-SNP captures two SNPs in complete linkage disequilibrium (r2= 1), both located within the 17th intron of the EVI5 gene. Our findings agree with the corresponding data of the recent IMSGC study and present new genetic evidence that points to EVI5 as a factor of susceptibility to MS. © 2010 Macmillan Publishers Limited All rights reserved.
2012-10-11T10:36:07Z
2012-10-11T10:36:07Z
2010
2012-10-11T10:36:08Z
artículo
European Journal of Human Genetics 18(7): 827- 831 (2010)
http://hdl.handle.net/10261/57890
10.1038/ejhg.2009.240
20087403
eng
closedAccess
Nature Publishing Group